Data for: UFL1 Modulates NLRP3 Inflammasome Activation and Protects Against Pyroptosis in LPS-stimulated Bovine Mammary Epithelial Cells

• LPS triggers NLRP3 inflammasome activation in BMECs • UFL1 modulates NLRP3 inflammasome activation in LPS-stimulated BMECs • UFL1 modulates the NLRP3 activation via regulation of NF-κB and ROS production • UFL1 alleviates LPS-induced pyroptosis by targeting NLRP3 inflammasome activation• 脂多糖（Lipopolysaccharide, LPS）可触发脑微血管内皮细胞（Brain Microvascular Endothelial Cells, BMECs）内的NLRP3炎性小体（NLRP3 inflammasome）活化 • UFL1可在脂多糖刺激的脑微血管内皮细胞中调控NLRP3炎性小体的活化 • UFL1通过调控核因子κB（Nuclear Factor kappa-light-chain-enhancer of activated B cells, NF-κB）的活性与活性氧（Reactive Oxygen Species, ROS）的生成，调控NLRP3的活化过程 • UFL1可通过靶向调控NLRP3炎性小体的活化，减轻脂多糖诱导的细胞焦亡（pyroptosis）