Effects sizes of the obesity risk alleles on measures of glucose homeostasis, with and without adjustments for BMI in the population-based Inter99 cohort.

Data are presented as effect sizes (95% CI) per allele and p-values.aEffect sizes are adjusted for age, sex and BMI and are given as percentages since the traits are logarithmically transformed, and p-values are specified for the additive model and adjusted for age, sex and BMI. P-values without a are only adjusted for age and sex. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated as ((fasting plasma glucose (mmol/l)×fasting serum insulin (pmol/l))/22.5). Insulinogenic index was calculated as ((serum insulin 30 minuttes post-oral glucose tolerance test (pmol/l) – fasting serum insulin (pmol/l)/plasma glucose 30 minuttes post-oral glucose tolerance test (mmol/l)).