Impact of the expression levels of intratumoral DPD ((A) DPD protein expression and (B) DPD mRNA expression) on disease-free survival.

(A) Clinical variables that had P 0]) were included in this multivariate analysis using a Cox proportional hazards model. A backward stepwise conditional regression was used with P = 0.10 as the entry and P = 0.10 as the removal criteria. Abbreviations: IHC, immunohistochemistry; DPD, dihydropyrimidine dehydrogenase; TP, thymidine phosphorylase.(B) Clinical variables that had P Impact of the expression levels of intratumoral DPD ((A) DPD protein expression and (B) DPD mRNA expression) on disease-free survival.