Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with 2-(2-hydroxyethoxy)ethylthiomethyl-DADMe-Immucillin-A

Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with 2-(2-hydroxyethoxy)ethylthiomethyl-DADMe-Immucillin-A Descriptor: (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-(2-{[2-(2-hydroxyethoxy)ethyl]sulfanyl}ethyl)pyrrolidin-3-ol, Aminodeoxyfutalosine nucleosidase, SULFATE ION Authors: Cameron, S.A, Wang, S, Almo, S.C, Schramm, V.L. Deposit date: 2014-10-02 Release date: 2015-11-25 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.58 Å) Cite: New Antibiotic Candidates against Helicobacter pylori. J.Am.Chem.Soc., 137, 2015

幽门螺杆菌（Helicobacter pylori）5'-甲硫腺苷/S-腺苷同型半胱氨酸核苷酶（MTAN）与2-(2-羟基乙氧基)乙基硫甲基-DADMe-Immucillin-A结合的晶体结构。结构描述：(3R,4S)-1-[(4-氨基-5H-吡咯并[3,2-d]嘧啶-7-基)甲基]-4-(2-{[2-(2-羟基乙氧基)乙基]硫烷基}乙基)吡咯烷-3-醇、氨基脱氧夫他洛辛核苷酶、硫酸根离子（SULFATE ION）。作者：Cameron, S.A.、Wang, S.、Almo, S.C.、Schramm, V.L.。提交日期：2014-10-02；发布日期：2015-11-25；最后修改日期：2023-09-27。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.58埃（Å）。引用文献：《抗幽门螺杆菌新型候选抗生素》，《美国化学会志》（J.Am.Chem.Soc.），137卷，2015年。