Design of weakly basic thrombin inhibitors incorporating novel P1 binding functions: molecular and X-ray crystallographic studies.

Design of weakly basic thrombin inhibitors incorporating novel P1 binding functions: molecular and X-ray crystallographic studies. Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha Thrombin, N4-(N,N-DIPHENYLCARBAMOYL)-AMINOGUANIDINE, ... Authors: De Simone, G, Menchise, V, Omaggio, S, Pedone, C, Scozzafava, A, Supuran, C.T. Deposit date: 2003-01-16 Release date: 2003-08-26 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: DESIGN OF WEAKLY BASIC THROMBIN INHIBITORS INCORPORATING NOVEL P1 BINDING FUNCTIONS: MOLECULAR AND X-RAY CRYSTALLOGRAPHIC STUDIES Biochemistry, 42, 2003

含新型P1结合功能的弱碱性凝血酶抑制剂设计：分子与X射线晶体学研究。描述符：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、α-凝血酶（Alpha Thrombin）、N4-(N,N-二苯基氨基甲酰基)-氨基胍……。作者：德·西蒙尼（De Simone, G）、门奇塞（Menchise, V）、奥马焦（Omaggio, S）、佩多内（Pedone, C）、斯科扎法瓦（Scozzafava, A）、苏普兰（Supuran, C.T.）。提交日期：2003-01-16；发布日期：2003-08-26；最后修改日期：2024-11-13。实验方法：X射线衍射（分辨率1.9 Å）。引用文献：《含新型P1结合功能的弱碱性凝血酶抑制剂设计：分子与X射线晶体学研究》，《生物化学（Biochemistry）》，第42卷，2003年。