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Genomic analyses to identify metabolic vulnerabilities

NIAID Data Ecosystem2026-05-01 收录

癌症代谢脆弱性

PDX模型基因组分析

数据链接：

https://www.omicsdi.org/dataset/ega/EGAS00001007244 数据链接链接失效反馈

官方服务：

资源简介：

Genomic analyses to identify metabolic vulnerabilities on PDX samplesEGA study EGAS00001007244

应用场景：

创建时间：

2023-05-22

癌症代谢脆弱性

多胺代谢调控

Aneuploidy, having an unbalanced genome, is an aberration commonly found in tumours but rare in normal tissues. It gives rise to proteotoxic stress as well as a stereotypical oxidative shift which mak

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Pooled CRISPR-Cas9 screens for metabolic liabilities in Hurthle cell carcinoma

癌症代谢脆弱性

CRISPR-Cas9

A metabolic hallmark of cancer identified by Warburg is the increased consumption of glucose and secretion of lactate, even in the presence of oxygen. Although many tumors exhibit increased glycolytic

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De Novo Pyrimidine Synthesis Is a Collateral Metabolic Vulnerability in NF2-deficient Mesothelioma

癌症代谢脆弱性

合成致死靶点

Pleural mesothelioma (PM) is one of the deadliest cancers, with limited therapeutic options due to its therapeutically intractable genome, which is characterized by the functional inactivation of tumo

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Table S4 from De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression

癌症代谢脆弱性

功能基因组筛选

CRISPR screen results for mouse Yumm5.2 cells

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Table S2 from De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression

嘌呤代谢

癌症代谢脆弱性

Primers used in this study

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