CHD3 and CHD4 coordinate gene expression programs to maintain Ã-cell function and identity in vivo [RNA-seq]
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https://www.ncbi.nlm.nih.gov/sra/SRP622025
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To establish the role of CHD3 and CHD4 on controlling gene expression programs in the beta cell, we generated a tamoxifen-inducible, beta-cell-specific knockout mouse models; control (MIP-CreERT; Chd3+/+; Chd4+/+; R26RtdTomato), Chd3Db (MIP-CreERT; Chd3f/f; Chd4+/+; R26RtdTomato) and Chd3/4Db (MIP-CreERT; Chd3f/f; Chd4f/f; R26RtdTomato) Overall design: Dispersed islets from tamoxifen treated control, Chd3Db and Chd3/4Db mice were flow-sorted, and RNASeq performed. Chd4Db Samples were uploaded under Series GSE217445. *************************************************************** The table below lists GEO accessions reused/reanalyzed for this study. ***************************************************************
创建时间：
2026-02-22
