Loss of DHX36 drives genome instability and regulates innate immune gene expression in cancer cells

This study aimed to explore the role of G-quadruplexes (G4) and DHX36 helicase in maintaining genome integrity at regulatory regions to better understand fragility associated with G4s and transcriptional changes driven by NF-kappaB signaling pathway activation and cytokine production, emphasizing DHX36/G4 role in genome instability and inflammation within the context of cancer.