Expression data from stabilized epithelial pancreatic cancer cells

Pancreatic ductal adenocarcinoma is therapeutically recalcitrant and metastatic. Epithelial to mesenchymal transition (EMT) is associated with metastasis, however, a causal connection needs further unraveling. We explored the impact of stabilized EMT states on PDAC metastasis through the use of genetically-engineered mouse models that exhibit a stabilized epithelial phenotype through the deletion of EMT-driving transcription factors Snail and Twist together We examined the cancer cell-intrinsic pathways associated with stabilized epithelial pancreatic adenocarcinoma cells. YFP+ cancer cells were freshly sorted from the primary pancreatic tumors and the most common metastatic sites, liver and lung, of the KPC and KPC;Snai1cKO; Twist1cKO mice for global expression profiling using the Clariom D mouse whole transcriptome array.