Gene expression profie at single cell level of lung cells in healthy rats and rats with pulmonary hypertension treated with sham-stimulation or ultrasound

Focused ultrasound of the spleen is an emerging therapeutic modality and recent reports have shown efficacy in reducing inflammation. We used scRNA seq to identify the gene expression changes in lungs of healthy animals, animals with pulmonary hypertension treated with focused ultrasound of the spleen or sham stimulation.脾脏聚焦超声（Focused ultrasound of the spleen）是一种新兴治疗手段，近期研究已证实其可有效减轻炎症。本研究采用单细胞RNA测序（scRNA-seq），对健康动物、经脾脏聚焦超声治疗的肺动脉高压动物以及接受假刺激的肺动脉高压动物的肺部基因表达变化进行了分析。