Room temperature XFEL Isopenicillin N synthase structure in complex with Fe and ACV under anaerobic conditions.

Room temperature XFEL Isopenicillin N synthase structure in complex with Fe and ACV under anaerobic conditions. Descriptor: FE (II) ION, Isopenicillin N synthase, L-D-(A-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE, ... Authors: Rabe, P, Kamps, J.J.A.G, Sutherlin, K, Pharm, C, McDonough, M.A, Leissing, T.M, Aller, P, Butryn, A, Linyard, J, Lang, P, Brem, J, Fuller, F.D, Batyuk, A, Hunter, M.S, Pettinati, I, Clifton, I.J, Alonso-Mori, R, Gul, S, Young, I, Kim, I, Bhowmick, A, ORiordan, L, Brewster, A.S, Claridge, T.D.W, Sauter, N.K, Yachandra, V, Yano, J, Kern, J.F, Orville, A.M, Schofield, C.J. Deposit date: 2020-06-05 Release date: 2021-06-09 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.4 Å) Cite: X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis. Sci Adv, 7, 2021

本数据集为厌氧条件下室温中，与亚铁离子（Fe(II)）、ACV结合的青霉素N合成酶（Isopenicillin N synthase）的X射线自由电子激光（X-ray Free Electron Laser, XFEL）结构。相关描述项包括：亚铁离子（Fe(II)）、青霉素N合成酶、L-D-(α-氨基己二酰)-L-半胱氨酰-D-缬氨酸（L-D-(A-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE）等。作者：Rabe P、Kamps J.J.A.G、Sutherlin K、Pharm C、McDonough M.A、Leissing T.M、Aller P、Butryn A、Linyard J、Lang P、Brem J、Fuller F.D、Batyuk A、Hunter M.S、Pettinati I、Clifton I.J、Alonso-Mori R、Gul S、Young I、Kim I、Bhowmick A、ORiordan L、Brewster A.S、Claridge T.D.W、Sauter N.K、Yachandra V、Yano J、Kern J.F、Orville A.M、Schofield C.J。沉积日期：2020-06-05；发布日期：2021-06-09；最后修改日期：2024-01-24。实验方法：X射线衍射（分辨率1.4 Å）。引用文献：X射线自由电子激光研究揭示青霉素N合成酶催化过程中的协同运动，《Science Advances》，7卷，2021年。