数据链接：
官方服务：
资源简介：
Drp1 interactome in neurons derived from HD patient iPS cells
应用场景：
创建时间：
2019-02-24
相关数据集
Examination of gene expression in cerebellum and hippocampus for mouse C57BL/6J WT and nmf205-/-
Ribosome stalling during translation has recently been shown to cause neurodegeneration, yet the signaling pathways triggered by stalled elongation complexes are unknown. To investigate these pathw
NIAID Data Ecosystem100
Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS
Ubiquitous expression of ALS-causing mutations in superoxide dismutase 1 (SOD1) provoke non-cell autonomous paralytic disease. By combining ribosome affinity purification and high-throughput sequencin
NIAID Data Ecosystem40
Senataxin, the helicase mutated in AOA2 and ALS4, plays a role in autophagy regulation [HTS]
Senataxin (SETX) is an RNA/DNA helicase that has been implicated in transcriptional regulation and the DNA damage response, through resolution of R-loop structures. Mutations in SETX result in either
NIAID Data Ecosystem20
AAGGG repeat expansions trigger RFC1-independent synaptic dysregulation in human CANVAS Neurons. AAGGG repeat expansions trigger RFC1-independent synaptic dysregulation in human CANVAS Neurons
This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series
NIAID Data Ecosystem40
Loss of TREM2 reduces hyperactivation of progranulin deficient microglia but not lysosomal pathology [14 months]
GRN haploinsufficiency causes frontotemporal lobar degeneration and results in microglial hyperactivation, lysosomal dysfunction and TDP-43 deposition. To understand the contribution of microglial hyp
NIAID Data Ecosystem30
