Transcriptional Regulation of ER Genes in Fish under Heat Stress: Implications for Enhanced Heat Tolerance (PRJCA032713)

Under heat stress, endoplasmic reticulum (ER) stress and apoptosis are pivotal for sustaining homeostasis. However, the pre-transcriptional regulatory mechanisms and interactions underlying this process are still largely unknown. In this study, we investigated the epigenetic transcriptional regulatory mechanisms underlying the ER stress and apoptosis of largemouth bass (Micropterus salmoides) under heat stress (HS) using histological, biochemical, transcriptomic, and chromatin accessibility approaches after programmed heating (28?C, 32?C, 36?C, and 37.5?C). This comprehensive analysis elucidates the transcriptional attributes and epigenomic landscape under heat stress, offering novel insights into the transcriptional regulation in such conditions. These findings elucidate the consequences of altered interactions within the transcriptional regulation of ER genes under heat stress and provide a theoretical basis for enhancing the ability of fish species to cope with heat stress.