Small molecule binding data for protein Platelet-derived growth factor receptor alpha/beta, Programmed cell death 1 ligand 1, and Programmed cell death 1 ligand 2, Uniprot P05622, P26618, Q9BQ51, Q9EP

DataCite Commons2024-04-26 更新30

A potent and selective small-molecule degrader of ENL suppresses leukemia progression in vivo (ChIP-Seq)

白血病靶向治疗

蛋白降解靶向嵌合体

ENL, a stoichiometric component of the Super Elongation Complex (SEC) as well as the histone H3K79 methyltransferase DOT1L complex, is involved in the regulation of transcription elongation. Loss-of-f

NIAID Data Ecosystem30

Genetic and chemical targeting of the ATPase complex TIP48 and 49 impairs acute myeloid leukemia

白血病靶向治疗

ATP（三磷酸腺苷）

The chromatin-associated AAA+ ATPases Tip48 and Tip49 are the core components of various complexes implicated in diverse nuclear events such as DNA repair and gene regulation. Although they are freque

NIAID Data Ecosystem60

Discovery of a Novel Class of Bioactive Molecules Suppressing Pathogenic Fibroblast Activation through Hyou1 Targeting

纤维化疾病靶向治疗

小分子药物

Fibroblasts play an important role in fibrosis, chronic inflammatory diseases (CIDs) and cancer. Targeting their pathogenicity is crucial, considering the limitations and side effects of existing biol

NIAID Data Ecosystem30

Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

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