Viral RNA-binding protein KSHV ORF57 and host transcriptome

Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a viral RNA-binding protein ORF57 that plays an essential role in posttranscriptional regulation of viral gene expression. Ectopice expression of KSHV ORF57 in HEK293T cells was evaluated on its effect on host gene expression in the study, with the cells transfected with an empty vector serving as a control. Overall design: A differential expression analysis of host transcritome in HEK293T cells ORF57 expressing vector (pVM7) or empty vector (pCMV5.1-FLAG).