RNA binding protein DDX3X drives pancreatic cancer progression via the TLE2-MYL9 axis

This project aimed to investigate the role of DDX3X in pancreatic cancer. We found dysregulation of DDX3X in the tumor destabilized TLE2 mRNA and thereby disrupted the interaction with KLF4, leading to increased expression of myosin light chain 9 (MYL9). This enhanced tumor cell traction forces and consequently facilitating tumor metastasis.