Downregulated CDH3 is significantly correlated with better prognosis from lung adenocarcinomas and decreases proliferation and migration in lung cancer cells in vitro

CDH3 is a single-span transmembrane domain glycoprotein that mediates cell-cell adhesion. It is normally expression in basal cells, luminal epithelial cells and monocytes of lung airway epithelial cells. However, the CDH3 gene is also frequently overexpressed in many cancers. Expression of CDH3 is an indicator of poor prognosis in human breast cancer and a marker for real-time monitoring of resistance to first/second generation EGFR-TKIs. In this present manuscript, we describe that high CDH3 expression is correlated with shorter overall survival of patients in lung adenocarcinomas and low CDH3 expression inhibits cells’ proliferation and migration Different gene expression in H1299 and HCC827 cells with transient CDH3 knockdown at 48 post-transfection hrs.