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Enantioselective Bromoaminocyclization Using Amino–Thiocarbamate Catalysts

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NIAID Data Ecosystem2026-03-07 收录
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A facile and efficient enantioselective bromoaminocyclization of unsaturated sulfonamides has been developed using an amino–thiocarbamate catalyst. A range of enantioenriched pyrrolidines were prepared with up to 99% yield and 99% ee. The corresponding lactams could be obtained through oxidation of the pyrrolidines.

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2011-06-22
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