Human Protein Atlas - Pathology Atlas

The Pathology Atlas contains mRNA and protein expression data from 17 different forms of human cancer. Correlation analyses based on mRNA expression levels of human genes in cancer tissue and the clinical outcome for almost 8000 cancer patients is presented in a gene-centric manner, and includes more than 18000 Kaplan-Meier plots with high significance (p<0.001). In addition, immunohistochemistry (IHC) analysis using a tissue microarray (TMA)-based analysis of the corresponding proteins in patients with the respective cancer types is presented for a majority of the protein-coding genes, constituting altogether more than 5 million IHC cancer tissue images. All transcriptomics data has been retrieved from the Cancer Genome Atlas and all proteomics data has been generated in-house using the same antibodies as in protein expression profiling in normal human tissues.

病理图谱汇集了来自17种不同类型人类癌症的mRNA和蛋白质表达数据。该图谱以基因为中心，展示了基于癌症组织中人类基因mRNA表达水平与近8000名癌症患者临床结局的相关性分析，并包含了超过18000个具有高度显著性（p<0.001）的Kaplan-Meier生存曲线图。此外，对于大多数蛋白质编码基因，还展示了基于组织微阵列（TMA）的免疫组织化学（IHC）分析，分析了相应蛋白质在各自癌症类型患者中的表达情况，总计构成了超过500万张IHC癌症组织图像。所有转录组数据均来自癌症基因组图谱，所有蛋白质组数据均在本单位使用与正常人类组织蛋白质表达分析中相同的抗体进行生成。