Gold-Catalyzed Tandem 1,3-Migration/Double Cyclopropanation of 1‑Ene-4,<i>n</i>‑diyne Esters to Tetracyclodecene and Tetracycloundecene Derivatives

A synthetic method that relies on Au­(I)-catalyzed tandem 1,3-acyloxy migration/double cyclopropanation of 1-ene-4,9-diyne and 1-ene-4,10-diyne esters to construct the respective architecturally challenging tetracyclodecene and tetracycloundecene derivatives is described. Achieved under mild reaction conditions, the transformation was shown to be robust with a wide variety of substitution patterns tolerated to give the two members of the carbocyclic family in good to excellent yields and as a single regio- and diastereomer.