Supplementary material to \"Healthcare resource use associated with tumor-induced osteomalacia: a literature review\"

Tumor-induced osteomalacia (TIO) is an ultra-rare, paraneoplastic syndrome caused by tumors that secrete fibroblast growth factor 23 (FGF23). Initial signs and musculoskeletal symptoms can be non-specific and unrecognized, leading to long delays in diagnosis and treatment, which results in severe and progressive disability in patients with TIO. This review aimed to identify published evidence on healthcare resource use in TIO to better understand the burden of the disease. A targeted literature review was conducted to identify publications reporting on disease characteristics and healthcare resource use associated with TIO. In total, 414 publications were included in the review, of which 376 were case reports. From the case reports, data on 621 patients were extracted. These patients had a mean (standard deviation) age of 46.3 (15.8) years; 57.6% were male. The mean time from first symptoms to diagnosis of TIO was 4.6 (4.7) years and, in cases where imaging tests were reported, patients..., , , # Supplementary material to \"Healthcare resource use associated with tumor-induced osteomalacia: a literature review\"

[https://doi.org/10.5061/dryad.stqjq2c9j](https://doi.org/10.5061/dryad.stqjq2c9j)

The supplementary material comprises two sections:

* Supplementary information to the Methods – Search strategies section of the review
* A list of all publications reported on in the review (case report studies and aggregate level studies)

## Description of the data and file structure

Table 1 is a list of search terms used during the database search of publications and the number of results for each term.

Table 2 and Table 3 list all case report studies and aggregate-level studies, respectively, included in the review. The list includes authors' names, publication titles, year of publication, and DOI.