C. elegans LPIN-1 moderates lifespan-shortening effects of dietary glucose via maintaining ?-6 polyunsaturated fatty acids

A glucose-rich diet shortens lifespan via altering lipid metabolism in many organisms, including Caenorhabditis elegans. However, it remains incompletely understood how glucose and lipid metabolism regulates lifespan. Here, we show that Lipin 1/LPIN-1, a phosphatidic acid phosphatase and a putative transcription co-regulator that mediates glucose-to-triacylglyceride synthesis, prevents the life-shortening effects of glucose-rich diets on C. elegans. We showed that the expression levels of many genes related to lipid metabolism were differentially regulated by lpin-1 RNAi and glucose treatment. Overall design: The investigation of the changes of gene expression in lpin-1 RNAi-treated animals on control diets or glucose-rich diets