Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric compound IDEAYA cmpd A

Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric compound IDEAYA cmpd A Descriptor: 7-chloranyl-4-[(3R)-3-fluoranylpyrrolidin-1-yl]-1-phenyl-quinazolin-2-one, CHLORIDE ION, GLYCEROL, ... Authors: Thomsen, M, Thieulin-Pardo, G, Neumann, L. Deposit date: 2023-05-21 Release date: 2023-08-30 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Discovery of novel methionine adenosyltransferase 2A (MAT2A) allosteric inhibitors by structure-based virtual screening. Bioorg.Med.Chem.Lett., 94, 2023人类甲硫氨酸腺苷转移酶2A（methionine adenosyltransferase 2A, MAT2A）与S-腺苷甲硫氨酸（SAM）以及变构化合物IDEAYA cmpd A结合的晶体结构。配体描述：7-氯-4-[(3R)-3-氟吡咯烷-1-基]-1-苯基喹唑啉-2-酮、氯离子、甘油……。作者：Thomsen M、Thieulin-Pardo G、Neumann L。提交日期：2023-05-21；发布日期：2023-08-30；最后修改日期：2024-10-23。研究方法：X射线衍射（分辨率1.71 Å）。引用文献：《基于结构虚拟筛选发现新型甲硫氨酸腺苷转移酶2A（MAT2A）变构抑制剂》，《Bioorg.Med.Chem.Lett.》，第94卷，2023年。