Suppression of SOX7 by DNA methylation and its tumor suppressor function in acute myeloid leukemia

ChEBI2015-04-14 更新2026-07-21 收录

急性髓系白血病表观遗传

肿瘤基因功能验证

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Suppression of SOX7 by DNA methylation and its tumor suppressor function in acute myeloid leukemia

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2015-04-14

Table 5_Local Promoter Methylation Disorder algorithm reveals bidirectional epigenetic disruption in DNMT3A-mutated AML and predicts azacitidine treatment response.xlsx

急性髓系白血病表观遗传

治疗反应预测

BackgroundDNMT3A mutations occur in 20-25% of acute myeloid leukemia (AML) cases and are associated with poor prognosis, yet the epigenetic mechanisms underlying treatment response remain poorly under

NIAID Data Ecosystem80

Supplementary Table 7 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

急性髓系白血病表观遗传

超级增强子与药物靶点分析

GO Analysis from Regions of Differential MOLM13 H3K27Ac CUT&Tag (6 Hours After Drug Treatment) Pileup at Enhancers and Promoters

NIAID Data Ecosystem50

Human HPV16 positive CaSki cells: Control vs. virus oncogene e6/e7 silenced

HPV致癌机制

肿瘤基因功能验证

Human HPV16 positive CaSki cells: Control vs. virus oncogene e6/e7 silenced

ChEBI2016-07-01 更新40

Inhibitors of LSD1 target demethylase-independent activity to induce differentiation in acute myeloid leukemia [anti-H3K9 ac, anti-H3K27, RCOR1, SPI1, and MLL4 ChIP-Seq]. Inhibitors of LSD1 target demethylase-independent activity to induce differentiation in acute myeloid leukemia [anti-H3K9 ac, anti-H3K27, RCOR1, SPI1, and MLL4 ChIP-Seq]

急性髓系白血病表观遗传

LSD1抑制剂

To determine whether changes in histone modifications directly correlate with changes in transcription, THP1 AML cells were treated with a potent and selective LSD1 inhibitor (OG86, 250nM) and then su

NIAID Data Ecosystem60

H3K9 acetylation and di-methylation changes in HL-60 cells following treatment with different compounds. H3K9 acetylation and di-methylation changes in HL-60 cells following treatment with different compounds

急性髓系白血病表观遗传

药物响应蛋白质组学

We investigate the effects of GCN5 and LSD1 inhibition in acute myeloid leukemia. Therefore, we characterized acetylation and di-methylation changes by ChIP-seq in AML cells (AML M2 cell line HL-60) f

NIAID Data Ecosystem50

Suppression of SOX7 by DNA methylation and its tumor suppressor function in acute myeloid leukemia

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