Polymorphisms in L. tropica isolatesa,b.
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aNucleotide polymorphisms and corresponding amino acid changes are shown.bThe polymorphisms in bold cause an amino acid substitution.cThe polymorphisms indicated were common to every L. tropica isolates analyzed, except for PGD, G6PDH, and SAD, which were not polymorphic in L. tropica MHOM/SU/74/K27.dFor nucleotide numbering, +1 corresponds to the A of the ATG translation initiation codon.PTR1 – pteridine reductase 1; NH1 – nucleoside hydrolase 1; DHFRTS – dihydrofolate reductase-thymidylate synthase; SAD – stearic acid desaturase; GPI – glucose-6-phosphate isomerase; PGD – 6-phosphogluconate dehydrogenase; ASAT – aspartate aminotransferase; G6PDH – glucose-6-phosphate dehydrogenase.
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2015-12-02



