Co-crystal structure of human serine hydroxymethyltransferase 2 in complex with Pyridoxal 5'-phosphate (PLP) and glycodeoxycholic acid

Co-crystal structure of human serine hydroxymethyltransferase 2 in complex with Pyridoxal 5'-phosphate (PLP) and glycodeoxycholic acid Descriptor: (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, GLYCINE, Serine hydroxymethyltransferase, ... Authors: Ota, T, Senoo, A, Ito, S, Ueno, G, Nagatoishi, S, Tsumoto, K, Sando, S. Deposit date: 2020-03-11 Release date: 2021-01-20 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.30000663987 Å) Cite: Structural basis for selective inhibition of human serine hydroxymethyltransferase by secondary bile acid conjugate. Iscience, 24, 2021

人丝氨酸羟甲基转移酶2（human serine hydroxymethyltransferase 2）与5'-磷酸吡哆醛（Pyridoxal 5'-phosphate, PLP）及甘氨脱氧胆酸结合的共晶体结构。描述符：(3α,5β,12α)-3,12-二羟基胆烷-24-羧酸、甘氨酸、丝氨酸羟甲基转移酶等。作者：Ota T、Senoo A、Ito S、Ueno G、Nagatoishi S、Tsumoto K、Sando S。沉积日期：2020年3月11日；发布日期：2021年1月20日；最后修改日期：2023年11月29日。实验方法：X射线衍射（2.30000663 Å）。引用文献：《次级胆汁酸结合物选择性抑制人丝氨酸羟甲基转移酶的结构基础》，发表于《Iscience》2021年第24卷。