Transcriptome sequencing (RNA-Seq) of PAT cells in CAD and control patients for exploring the association between CAD and PAT

Coronary artery disease (CAD) poses a worldwide health threat. Compelling evidence shows that pericardial adipose tissue (PAT), a brown-like adipose adjacent to the external surface of the pericardium, is associated with CAD. However, the specific molecular mechanisms of PAT in CAD are elusive. For characterizing human PAT and explore its association with CAD, the transcriptome characteristics were assessed in 5 CAD patients and 4 controls via RNA-sequencing. Overall design: mRNA profiles of PAT cells in CAD and control patients were generated by deep sequencing, using Illumina NovaSeq 6000.