Whole transcriptome analysis of liver tissue from SAMP8 mice treated with the Alzheimer’s disease drug J147. Whole transcriptome analysis of liver tissue from SAMP8 mice treated with the Alzheimer’s disease drug J147

Alzheimer’s disease (AD) drug discovery has rarely been addressed in the context of aging even though sporadic AD accounts for 99% of the cases. Previous phenotypic screens based upon old age-associated brain toxicities identified the potent AD drug candidates CMS121 and J147, whose mechanisms were investigated through an integrative multi-omics approach (PMID: 31742554; GSE101112). This study aimed to further reveal drug J147's role involved in liver metabolism during disease progression. Overall design: 9 month-old (young) and 13 month-old (old) SAMP8 mice were fed with vehicle diet, another group of SAMP8 mice were fed with J147 for 4 months and sacrified at their 13 month-old age. RNA were extracted from liver tissue.