Valine tRNA biogenesis and bioavailability regulates mitochondrial complex I levels in acute leukemia [RNAseq]

We report the effects on gene expression on dietary modulation of valine in an in vivo model of T cell acute lymphoblastic leukemia Overall design: Examination of changes in the RNA transcripts following either NOTCH1-inhibition in human cell line or dietary modulation of valine in an in vivo model of T cell acute lymphoblastic leukemia.