Appendix S1 - Cost-Effectiveness and Harm-Benefit Analyses of Risk-Based Screening Strategies for Breast Cancer

Supporting information on methods used and results obtained, containing Tables S1 to S15 and Figures S1 to S7. Table S1, Distribution of stages at diagnosis of BC. Table S2, Relative risk of breast cancer based on age and breast density. Table S3, Prevalences of risk factors by age group for each category of breast density. Table S4, Characteristics of the 2,625 screening strategies analized. Table S5, The utilities for the general population and for women diagnosed with BC, either DCIS or invasive. Table S6, Model for false positives of non-invasive tests. Table S7, Model for false positives of invasive tests. Table S8, Distribution of stages at diagnosis of BC for screen-detected cases. Different overdiagnosis rates. Table S9, Linear regression model with dependent variable being the DCIS rate per women-year. Table S10, Cost-effectiveness and harm-benefit analysis. Lives extended. Table S11, Cost-effectiveness and harm-benefit analysis. Quality-adjusted life years (QALY). Table S12, Number of mammograms and detection rates for screen-detected and interval cases and program sensitivity by age groups. Invasive cancer (DCIS not included). Table S13, Distribution of stages at diagnosis of BC. Table S14, Sensitivity analysis. Changes in lives extended. Table S15, Sensitivity analysis. Changes in QALY. Figure S1, Incidence curves for twelve risk profiles grouped by risk level: (A) Low Risk, (B) Medium-Low Risk, (C) Medium-High Risk, and (D) High Risk. Graphic (E) shows the smoothed incidence rates for each risk group. Figure S2, Observed and smoothed DCIS rates over time in Catalonia (1983–2008). Figure S3, Index of mammography use (IMU) and smoothed DCIS rates over time in Catalonia (1983–2008). Figure S4, Cost-effectiveness and harm-benefit analyses for 2,625 early detection strategies, with uniform strategies marked. Effect measured in lives extended. Figure S5, Cost-effectiveness and harm-benefit analyses for 2,625 early detection strategies, with uniform strategies marked. Effect measured in QALY. Figure S6, Sensitivity analysis of a change in the risk groups distribution. Cost-effectiveness and harm-benefit analyses for 2,625 early detection strategies. Effect measured in lives extended. Figure S7, Sensitivity analysis of a change in the risk groups distribution. Cost-effectiveness and harm-benefit analyses for 2,625 early detection strategies. Effect measured in QALY.
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