Analysis of IRF5 transcripts containing the Ex6 in/del.

Using estimated transcript read counts obtained from MMSeq, expression of transcripts containing vs. those missing the Ex6c deletion was compared in healthy donors (n = 4) and SLE patients carrying the H2 risk haplotype (n = 4). Shown are the total number of reads aligned per group of patients. aχ2 = 1377726 with p−16; p values were obtained by the Pearson’s χ2-test with Yates continuity correction. Totaled reads mapping to the Ex6C deletion were similarly compared across grouped healthy vs. SLE (risk) patients; bχ2 = 16.0379 with p−15. Σ = sum.