Additional file 1 of TDP-43 seeding activity in the olfactory mucosa of patients with amyotrophic lateral sclerosis

Supplementary Material 1. Table S1. Comparison of SAA analyses and characteristics of the study population. The results of SAA analysis for TDP-43 and αSyn are listed for each subject: Sporadic MND, Genetic MND, Other neurodegenerative disorders, Controls. Abbreviations: POS = positive by SAA; NEG = negative by SAA; ID = identification; NA = not applicable; M = male; F = female; FOSMN = facial onset sensory and motor neuronopathy; bALS = bulbar-onset amyotrophic lateral sclerosis; sALS = spinal-onset amyotrophic lateral sclerosis; PLS = primary lateral sclerosis; MSA = multiple system atrophy; DLB = dementia with Lewy body; AD = Alzheimer's disease; CTRL = controls; ALS-FTD = ALS with frontotemporal dementia; ALScn = cognitively normal ALS; ALSci = ALS with cognitive impairment; ALSbi = ALS with behavioral impairment; ALScbi = ALS with combined cognitive and behavioral impairment; ALSnex = ALS with nonexecutive dysfunction; y = years; m = months; ALSFRSr_tot = ALS Functional Rating Scale revised total score; ΔFS = disease progression rate, calculated according to the following formula:/[disease duration at evaluation], as reported in Methods; BMI = body mass index; TARDBP = TAR DNA binding protein; C9orf72exp = Chromosome 9 open reading frame 72 expansion; SQSTM1= sequestosome 1; OPTN = optineurin; GLE1 = GLE1 RNA export mediator; het = heterozygous; hom = homozygous