PDE12 expression data from diabetes patients and controls

Type 1 diabetes (T1D) incidence is increased after COVID-19 infection in children under 18 years of age. Interferon-α-activated oligoadenylate synthetase and downstream RNAseL activation degrade pathogen RNA, but can also damage host RNA when RNAseL activity is poorly regulated. One such regulator is PDE12 which degrades 2′-5′ oligoadenylate units, thereby decreasing RNAseL activity. We analyzed PDE12 expression in islets from non-diabetic donors, individuals with newly (median disease duration 35 days) and recently (5 years) diagnosed T1D, and individuals with type 2 diabetes (T2D). We also analyzed PDE12 single-nucleotide polymorphisms (SNPs) relative to T1D incidence. PDE12 expression was decreased in individuals with recently diagnosed T1D, in three of five individuals with newly diagnosed T1D, but not in individuals with T2D. Two rare PDE12 SNPs were found to have odds ratios of 1.80 and 1.74 for T1D development. We discuss whether decreased PDE12 expression after COVID-19 infectio...1型糖尿病（Type 1 diabetes, T1D）在18岁以下儿童感染新型冠状病毒肺炎（COVID-19）后发病率升高。干扰素α激活的寡腺苷酸合成酶及其下游的核糖核酸酶L（RNase L）可降解病原体RNA，但当RNase L活性调控失常时，也会损伤宿主RNA。磷酸二酯酶12（PDE12）是此类调控因子之一，它可降解2'-5'寡腺苷酸，从而降低RNase L的活性。本研究分析了非糖尿病供体、新诊断（中位病程35天）与近期诊断（病程5年）的T1D患者，以及2型糖尿病（Type 2 diabetes, T2D）患者的胰岛组织中PDE12的表达水平；同时还分析了与T1D发病相关的PDE12单核苷酸多态性（SNPs）。结果显示，近期诊断的T1D患者、5名新诊断T1D患者中的3名，其PDE12表达水平均出现下调，而2型糖尿病患者则无此变化。研究发现2个罕见的PDE12 SNPs与T1D发病的比值比分别为1.80和1.74。本文将探讨新型冠状病毒肺炎感染后PDE12表达下调是否……