Postnatal neuronal Bace1 deletion impairs neuroblast and oligodendrocyte maturation

We aim to understand the effect of postnatal neuronal deletion of Bace1 on the transcriptome of the hippocampus Single nuclei from P31 and P192 Bace1-fl/fl and Bace1-fl/fl;Thy1-cre mice were isolated from snap frozen hippocampii本研究旨在探究出生后神经元特异性敲除Bace1对海马体转录组的影响。研究人员从快速冷冻的海马组织中分离了出生后第31天（P31）与第192天（P192）的Bace1-fl/fl及Bace1-fl/fl;Thy1-cre小鼠的单细胞核。