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资源简介：
study the mechanism of transformation from NSCLC into SCLC
应用场景：
创建时间：
2024-04-01
相关数据集
Frequency of driver gene alterations in different subgroups.
NSCLC: non-small cell lung cancer; NS with AC: patients with adenocarcinoma in non-smokers; S with AC: patients with adenocarcinoma in smokers; NS with SCC: patients with squamous cell carcinoma in no
Figshare2015-12-02 更新60
KDM6A Epigenetically Regulates Subtype Plasticity in Small Cell Lung Cancer (atac batch3). KDM6A Epigenetically Regulates Subtype Plasticity in Small Cell Lung Cancer (atac batch3)
Using a CRISPR-based autochthonous SCLC GEMM to study the consequences of KDM6A/UTX inactivation, we found that KDM6A inactivation induced plasticity from ASCL1 to NEUROD1 resulting in SCLC tumors wit
NIAID Data Ecosystem50
In-depth proteomic analyses reveal unique subtype-specific signatures in small cell lung cancer (part I: cell pellets)
Small-cell lung cancer (SCLC) represents about 13–15% of all lung cancers and with a five-year survival rate of less than 7%, it remains one of the most lethal forms of malignant diseases. It has a ve
NIAID Data Ecosystem40
Transcriptional circuitry of NKX2-1 and SOX1 defines a previously unrecognized lineage subtype of small cell lung cancer to maintain neuroendocrine differentiation (Fixed-tissue ChiP-Seq Human). Transcriptional circuitry of NKX2-1 and SOX1 defines a previously unrecognized lineage subtype of small cell lung cancer to maintain neuroendocrine differentiation (Fixed-tissue ChiP-Seq Human)
Molecular classification of small cell lung cancer (SCLC), a lethal and heterogeneous disease, was recently proposed based on expression of four lineage-defining transcription factors SCLC-A (ASCL1),
NIAID Data Ecosystem50
Multiomic Analysis of Lung Tumors Defines Pathways Activated in Neuroendocrine Transformation
To investigate the molecular mechanisms of neuroendocrine (NE) transformation, adenocarcinomas (LUAD) to small cell lung cancer (SCLC), in lung cancer. Overall design: We performed EPIC (methyl-captur
NIAID Data Ecosystem40
