Supplementary Material for: Transformation of Castleman disease into Angioimmunoblastic T cell Lymphoma complicated by Hemophagocytic lymphohistiocytosis: A case report and literature review

Introduction: Castleman's disease (CD) is a disease characterized by chronic lymphoid reactive hyperplasia. CD secondary angioimmunoblastic T cell lymphoma (AITL) with hemophagocytic lymphohistiocytosis (HLH) is a rare and fatal disease with rapid progression, poor treatment and poor prognosis. Case Presentation: We present a case of idiopathic multicentric CD-secondary AITL with HLH that achieved good therapeutic outcomes after treatment with ruxolitinib combined with CHOP regimen. The Epstein-Barr virus (EBV) in the peripheral blood of this patient remained positive throughout the course of the disease. Conclusion: EBV could be involved in the mechanism of CD conversion to AITL with HLH. Ruxolitinib combined with CHOP regimen may be a potentially effective treatment for this disease.