Clinical and histopathological features of 81 cases of canine apocrine gland carcinoma of the anal sac

Canine apocrine gland anal sac adenocarcinoma (AGASAC) is a malignant tumour with variable clinical progression. The objective of this study was to use robust multivariate models, based on models employed in human medical oncology, to establish clinical and histopathological risk factors of poor survival. Clinical data and imaging of 81 cases with AGASAC were reviewed. Tissue was available for histological review and immunohistochemistry in 49 cases. Tumour and lymph node size were determined using the response evaluation criteria in solid tumours system (RECIST). Modelling revealed tumour size over 2 cm, lymph node size grouped in three tiers by the two thresholds 1.6 cm and 5 cm, surgical management, and radiotherapy were independent clinical variables associated with survival, irrespective of tumour stage. Tumour size over 1.3 cm and presence of distant metastasis were independent clinical variables associated with first progression free interval. The presence of the histopathologica...犬肛周顶泌腺腺癌（Canine apocrine gland anal sac adenocarcinoma, AGASAC）是一类临床进展存在显著异质性的恶性肿瘤。本研究旨在基于人类肿瘤医学领域已应用的模型构建稳健多变量模型，以明确与不良生存结局相关的临床及组织病理学风险因素。研究回顾了81例确诊为AGASAC的病例的临床资料与影像学数据；其中49例病例留存有可用于组织学复核及免疫组化检测的组织样本。本研究采用实体瘤疗效评价标准（Response Evaluation Criteria in Solid Tumours, RECIST）测量肿瘤与淋巴结直径。建模分析结果显示，肿瘤直径＞2cm、以1.6cm和5cm为阈值划分的三级淋巴结直径分组、外科治疗与放疗为与生存情况相关的独立临床变量，且该关联不受肿瘤分期影响。此外，肿瘤直径＞1.3cm及存在远处转移为与首次无进展生存期相关的独立临床变量。组织病理学[原文未完整表述]