DNA methylation of candidate genes in peripheral blood from patients with type 2 diabetes or the metabolic syndrome.xlsx

No significant differences in gene-specific methylation between patients and controls were observed, although a trend towards significance was observed for <i>PEG3</i>. Differential methylation was observed between the groups in 4 out of the 42 single CpG loci located in the promoters regions of the genes <i>FTO</i>, <i>KCNJ11</i>, <i>PPARγ </i>and <i>PDK4</i>. A trend towards a positive correlation was observed for <i>PEG3</i> methylation with HDL cholesterol levels.