Characteristics of cancers associated with the KY screening cohort.

*Exclusion criteria included: (1) Current or prior personal history of lung cancer (2) Prior malignancy except adequately treated non-melanomatous skin cancer or in-situ cervical cancer.The table includes class prediction and temporal relationship of sample draw to cancer diagnosis. Binomial prediction is based on additive measures from the six-marker panel. Up to three individual sample measures from each subject are designated either positive (+) or negative (–) based on levels relative to a predetermined cutoff value of 640 FU (fluorescent units). Assay results at time-of-diagnosis (radiographic detection) of five screening detected lung cancers (three prevalence and two incidence cancers) are designated as “0” months. Two samples designated “+3” and “+15” were drawn 3 and 15 months respectively following a diagnosis of a stage I head and neck cancer in one participant of the lung cancer screening study.