Inhibition of epigenetic modifiers LSD1 and HDAC1 blocks rod photoreceptor death in mouse models of Retinitis Pigmentosa.. Inhibition of epigenetic modifiers LSD1 and HDAC1 blocks rod photoreceptor death in mouse models of Retinitis Pigmentosa.
收藏NIAID Data Ecosystem2026-03-12 收录
下载链接：
https://www.ncbi.nlm.nih.gov/bioproject/PRJNA716982
下载链接
链接失效反馈官方服务：
资源简介：
In retinitis pigmentosa mouse models inhibitors of histone modification enzymes LSD1and HDAC1 blocked rod degeneration, preserved vision and affected the expression of multiple genes including maintenance of rod-specific transcripts and downregulation those involved in inflammation, gliosis and cell death. Overall design: Total 11 samples of mouse retina at PN24: 2 wild type controls C57Bl/6J, 3 rd10 B6.CXB1-Pde6brd10/Jrd10, 3 wild type treated with GSK2879552 (LSD1 inhibitor) from PN9 till PN24 and 3 rd10 treated with GSK2879552 from PN9 till PN24
创建时间：
2021-03-24
