Two Cu(II) complexes: inhibitory activity on ovarian cancer cell proliferation, migration, and invasion ability via increasing miRNA16 expression
收藏DataCite Commons2020-12-04 更新2024-07-28 收录
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https://tandf.figshare.com/articles/dataset/Two_Cu_II_complexes_inhibitory_activity_on_ovarian_cancer_cell_proliferation_migration_and_invasion_ability_via_increasing_miRNA16_expression/12601658
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Two new Cu(II)-based coordination polymers (CPs) {[Cu<sub>3</sub>(btc)<sub>2</sub>(bpfp)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>](H<sub>2</sub>O)<sub>2</sub>}<i><sub>n</sub></i> (<b>1</b>, H<sub>3</sub>btc = 1,2,3-benzenetricarboxylic acid, bpfp = bis(4-pyridylformyl)piperazine) and {[Cu(cca)(bpfp)]·2H<sub>2</sub>O}<i><sub>n</sub></i> (<b>2</b>, H<sub>2</sub>cca = 2-carboxycinnamic acid) have been successfully prepared by reaction of Cu(NO<sub>3</sub>)<sub>2</sub>·3H<sub>2</sub>O with the bpfp ligand in the presence of different carboxylate ligands. Compounds <b>1</b> and <b>2</b> were synthesized for the evaluation of anti-cancer activity on the ovarian cancer cells CoC1. First of all, the cancer cell proliferation, migration and invasion ability were determined. Subsequently, the marker of the ovarian cancer cells-miRNA16 was also measured with real time reverse transcription-polymerase chain reaction (RT-PCR).
提供机构：
Taylor & Francis
创建时间：
2020-07-02
