P2Y14 receptor can bind to UDP-glucose

Uridine 5'-diphosphoglucose (UDP-glucose) has a well established biochemical role as a glycosyl donor in the enzymatic biosynthesis of glycogen and polysaccharides. UDP-glucose may also possess pharmacological activity and is found to activate the orphan receptor P2Y14 (KIAA0001) (Chambers JK et al, 2000). Nucleotides known to activate P2Y receptors were inactive towards P2Y14. This receptor's actions are mediated by coupling with the G protein alpha Gi/o which inhibits adenylyl cyclase and thus, reduces cAMP accumulation (Fricks IP et al, 2009).

尿苷-5'-二磷酸葡萄糖（UDP-葡萄糖）在糖原和多糖的酶促生物合成中充当一种已确立的糖苷供体，具有明确的生化功能。UDP-葡萄糖可能还具有药理活性，并已被发现能够激活孤儿受体P2Y14（KIAA0001）（Chambers JK 等人，2000年）。已知能够激活P2Y受体的核苷对P2Y14无效。该受体的作用通过与其G蛋白α亚基Gi/o的偶联介导，该亚基抑制腺苷酸环化酶，从而减少cAMP的积累（Fricks IP 等人，2009年）。