The mechanism of taurine inhibiting the growth of Listeria monocytogenes

Listeria monocytogenes, as a significant foodborne pathogen, is not frequently encountered, however, when infections do occur, they can prove highly lethal to specific populations. Antibiotics are still regarded as the primary treatment option for Listeria infections. Nevertheless, under the global antibiotic crisis, there is an urgent demand for innovative and alternative strategies. In our study, we identified taurine, a sulfur-containing free amino acid, as an effective inhibitor of Listeria growth. Furthermore, our findings revealed that taurine administration significantly reduced bacteria burden and concurrently mitigated host-derived inflammation in the mouse model. It was observed that taurine stimulated T cell proliferation and inhibited pyroptosis via MAPK and NLRP3/Caspase-1/GSDMD pathways. Our research outcomes position taurine as a promising therapeutic candidate for combating Listeria infections, with an inherent advantage of reduced likelihood for inducing antibiotic resistance compared to conventional antibiotic treatments.