Metabolic support by macrophages sustains colonic epithelial homeostasis in mice

NIAID Data Ecosystem2026-05-01 收录

免疫代谢

肠道上皮稳态

数据链接：

https://www.ncbi.nlm.nih.gov/sra/ERP150033 数据链接链接失效反馈

官方服务：

资源简介：

This dataset was generated to compare Tsc2 (tuberous sclerosis complex 2) Lyz2-cre mice (n=8) with inactivated Tsc2 (mTORC inhibitor) to Tsc2fl/fl mice (n=4) (steady state).

创建时间：

2023-09-24

Microbial Energy Metabolism Fuels a CSF2-dependent Intestinal Macrophage Niche within Solitary Isolated Lymphoid Tissues via purinergic signaling.. Microbial Energy Metabolism Fuels a CSF2-dependent Intestinal Macrophage Niche within Solitary Isolated Lymphoid Tissues via purinergic signaling.

免疫代谢

巨噬细胞生态位

Gene expression comparison across CD11b+ cells from Csf2-sufficient and deficient mice. Overall design: Steady state isolated CD11b+ cells from colon lamina propria or solitary isolated lymphoid tissu

NIAID Data Ecosystem70

DataSheet_1_Low-density lipoprotein balances T cell metabolism and enhances response to anti-PD-1 blockade in a HCT116 spheroid model.zip

免疫代谢

PD-1联合治疗

IntroductionThe discovery of immune checkpoints and the development of their specific inhibitors was acclaimed as a major breakthrough in cancer therapy. However, only a limited patient cohort shows s

NIAID Data Ecosystem30

ADAR1 controls macrophage scavenging and lipid-buffering programs in metabolic tissues

免疫代谢

RNA功能分析

Data Table 1. List of RNA editing events per gene and pathway analysis. Data Table 2. List of DEGs for siADAR1, siADAR1-p150 and overlapping and pathway analysis for each comparison. Data Table 3. L

Zenodo2026-04-15 更新20

D- 2-hydroxyglutarate is an immunometabolite that accumulates in macrophages after TLR activation and inhibits inflammatory responses

免疫代谢

巨噬细胞炎症抑制

Macrophages undergo extensive metabolic rewiring upon activation and this serves many roles beyond the production of energy and anabolic building blocks. So-called immunometabolites that accumulate up

NIAID Data Ecosystem30

Additional file 2 of DNA methylation changes in metabolic and immune-regulatory pathways in blood and lymph node CD4 + T cells in response to SIV infections

病毒感染表观遗传学

免疫代谢

Additional file 2. Supplementary Table 1. Description of animals used for characterization of DNA methylation during SIV infection.

NIAID Data Ecosystem30