Whole transcriptomic analysis of mechanisms of tolerance and resistance to chlorhexidine in carbapenemase-producing Klebsiella pneumoniae clinical strains

The increasing resistence and/or bacterial tolerance to bactericides, such as chlorhexidine, causes worrisome public health problems. Using transcriptomical and microbiological studies, we analysed the molecular mechanisms associated with the adaptation to chlorhexidine in two carbapenemase-producing strains of Klebsiella pneumoniae belonging ST258-KPC3 and ST846-OXA48. Overall design: In this study, we analized four clinical strains of Klebsiella pneumoniae producing carpabenemase, two of them adapted to chlorhexidine (ST258-KPC3CA and ST846-OXA48CA) and their respective controls (ST258-KPC3 and ST846-OXA48). For each strain there are four replicate. Statical analysis by DESeq2 and EdgeR.