Patterns of blood pressure response during intensive BP lowering and clinical events: results from the secondary prevention of small subcortical strokes trial

Purpose: We applied cluster analysis to identify discrete patterns of concomitant responses of systolic (SBP), diastolic (DBP) and pulse pressure (PP) during intensive BP lowering; and to evaluate their clinical relevance and association with risk of mortality, major vascular events (MVEs), and stroke. Material and methods: We used an unsupervised cluster procedure to identify distinct patterns of BP change during the first 9 months of anti-hypertensive therapy intensification among 1,331 participants in the Secondary Prevention of Small Subcortical Strokes Trial who were previously randomized to lower BP target (SBP

目的：本研究采用聚类分析方法，旨在识别在强化血压降低过程中，收缩压（SBP）、舒张压（DBP）及脉压（PP）的伴随反应的离散模式；并评估其临床意义及其与死亡率、主要血管事件（MVEs）及中风的关联。研究材料与方法：我们采用无监督聚类程序，对在二级预防小型皮质下卒中试验中随机分配至降低血压目标（SBP）的1,331名参与者在强化抗高血压治疗前9个月内的血压变化模式进行识别。