Monomeric Targeted Protein Degraders

The discovery and development of
targeted protein degraders have
become important areas of research in the field of medicinal chemistry.
Inducing degradation of a target protein presents several advantages
relative to simple inhibition including a potential for extended duration
of action and more profound pharmacology. While engineered heterodimeric
molecules have recently been a major focus within industry and academia,
this Perspective highlights examples of targeted protein degradation
observed for smaller, monomeric molecules. Methods and tools for evaluating
protein degradation as well as a discussion of physical properties
of monomeric vs engineered heterodimeric degraders are presented.