RAW DATD OF CCRL2 deficiency inhibits thermogenesis in mice by altering macrophage polarization

The findings highlight CCRL2 as a critical regulator of macrophage polarization and its effects on thermogenic signaling in sWAT. The study identifies a unique non-adrenergic pathway involving p38 MAPK phosphorylation, which challenges conventional understanding of thermogenesis promotion. These insights offer potential therapeutic avenues for addressing obesity by targeting macrophage-mediated metabolic disruptions.