Transcriptional adaptations of HUVECs exposed to high and low fluid shear stress

The goal of this study was to identify gene signatures in HUVECs exposed to atheroprone low laminar shear stress (LSS) or atheroprotective high laminar shear stress (HSS). The obtained data was used to verify that HSS and LSS application induces gene expression patterns similar to more complex pulsatile and oscillatory flow, respectively. Overall design: 3 biological replicates of HUVEC monolayers were subjected to HSS (30 dyne/cm^2) or LSS (1 dyne/cm^2). Cells cultured under static conditions were used as a control.