Raw Data on Genetic Variants and Muscular Fitness in a Follow-Up Study of Middle-Aged and Older Adults

This dataset from a longitudinal study provides comprehensive anthropometric and physical fitness data from participants at baseline and 2.7 years later. It includes measurements of height (to the nearest 0.5 cm) and weight (to the nearest 0.1 kg) for calculating BMI. Physical fitness was assessed using isometric handgrip strength, lower body strength (30-second chair-stand test), functional mobility (timed up-and-go test), and aerobic endurance (6-minute walk test), all demonstrating acceptable reliability (ICC > 0.7) within the Kosovo population. Additionally, genotypes were obtained from saliva samples, focusing on single nucleotide polymorphisms (SNPs) in the VDR (rs7975232, rs2228570, rs731236) and GC (rs4588, rs2282679) genes. Vitamin D status was determined exclusively at the follow-up measurements and analyzed for total 25-(OH)D levels using an enzyme-linked immunosorbent assay. This dataset enables the exploration of the impact of genetic variants on muscle fitness and vitamin D status in middle-aged and older adults in Kosovo.本数据集源自一项纵向研究，收录了受试者于基线阶段及随访2.7年后的全套人体测量学与体能测评数据。其中包含用于计算身体质量指数（Body Mass Index, BMI）的身高（精确至0.5厘米）与体重（精确至0.1千克）测量值。体能状况通过以下指标评估：等长握力、下肢力量（30秒坐站试验）、功能性活动能力（计时起立行走试验）及有氧耐力（6分钟步行试验），所有指标在科索沃人群中均表现出可接受的信度，其组内相关系数（Intraclass Correlation Coefficient, ICC）大于0.7。此外，研究通过唾液样本获取受试者基因型数据，重点聚焦维生素D受体（VDR）及GC基因中的单核苷酸多态性（Single Nucleotide Polymorphisms, SNPs），具体位点包括VDR基因的rs7975232、rs2228570、rs731236以及GC基因的rs4588、rs2282679。维生素D营养状况仅在随访阶段测定，通过酶联免疫吸附试验（enzyme-linked immunosorbent assay, ELISA）检测总25-羟维生素D[25-(OH)D]水平。本数据集可用于探究科索沃中老年人群中遗传变异对肌肉体能与维生素D营养状况的影响。